Agaricus Extract Research Summary

By Dr. Markho Rafael

In 1993, Japanese mycologists discovered and began to cultivate a new medicinal mushroom found in the fields northwest of Sao Paolo, Brazil. Best known by its Latin name as Agaricus blazei, it has rapidly become one of the top five most sought after medicinal mushrooms in the world.

Research on Agaricus extract has largely focused on its anti-cancer properties. Results on uterocervical cancers appear promising. [25]

Agaricus extract contains more beta glucans than any other mushroom species investigated. In addition to the research on Agaricus blazei itself, it may be worthwhile to look into the abundant research that has been done on beta glucans. [25]

Research on Agaricus extract against cancer cell cultures (in vitro) have yielded primarily negative results, but testing on live individuals (in vivo) have shown some positive results. What this tells us is that Agaricus blazei's effect on cancer is by stimulating the immune system rather than killing off cancer cells directly. [135, 136, 137, 138, 139, 140]

In fact, one Japanese study from 2002 showed that when stimulated by Agaricus extract, macrophages would deliver a two punch knockout to cancer cells. (Macrophages are a type of white blood cells.) Eight hours after taking Agaricus extract, the patient's macrophages excreted a cancer killing compound known as alpha tumor necrosis factor. Then four hours after that, the same macrophages excreted another compound specifically targeted to finish off the now weakened cancer cells. [141]

An additional cancer protective property of Agaricus extract is that it helps inhibit the production of aromatase, a human enzyme associated with breast cancer development. [142]

Alcohol and water extracts of Agaricus blazei mycelium ("roots") are both rich in potential medicinal compounds. [143, 25]

In addition to showing promise as cancer medicine, Agaricus extract also demonstrates antibacterial properties. In one study, it was particularly effective against salmonella. [144]

Finally a few words of caution: One test in 2003 showed that Agaricus blazei grown in China contained a significantly larger amount of cadmium than Agaricus grown in the United States. [145]

Secondly, although Agaricus extract has demonstrated some powerful anti-cancer properties, it also contains a family of cancer-inducing compounds known as agaritines. (These are also found in button mushrooms, crimini mushrooms and portobellos.)

In 2003, Stijve et al. published a comparative study of agaritines between Agaricus blazei from different sources. The extract of Paul Stamets' Agaricus blazei grown in Washington State contained eighty-fold less of the carcinogenic agaritines than the samples from China, and twenty times less than samples from California. [145]

"Years ago, Paul Stamets ... developed methods that precluded agaritines, and Stijve et al. (2003) published a comparison of commercial products from the US, China, and Japan. All but [Paul Stamets] products contained significant amounts of agaritine." [145]

In his book Mycelium Running, medicinal mushroom expert Paul Stamets also lists the following areas where research has shown Agaricus extract to have a beneficial effect: Viruses; Blood Sugar; Cholesterol; Colorectal Cancer; Sarcoma. [134]

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Always consult a licensed medical practitioner before using any herb (or mushroom) for medicinal purposes. - 17269

About the Author:

Dr. Rafael has worked with natural health since finishing Chiropractic College in 1996. He now focuses on medicinal mushrooms, including Extract of Agaricus, in cooperation with Cordyceps Reishi Extracts, LLC. For the scientific references to this article, go to the Agaricus blazei Extract page. Click on a reference number to find the reference.